Jing Chen

Title/Position
Assistant Professor of Dental Medicine (at CUMC)
Director of the Postgraduate Program in Orthodontics
Address
CDM - Orthodontics, Mail Code: P & S Box 20, United States
Contact
+1 212 342 1639
Research
  • Basic Science
Key word or phrase descriptors for area of expertise: 
Orthodontics, TMJ animal model

Dr. Jing Chen is interested in the molecular pathways that regulate temporomandibular joint (TMJ) growth and degeneration. The TMJ is composed of many types of cell at various stages of maturation. We have developed mouse models of mechanical loading induced TMJ remodeling and have extensively characterized how changing the occlusal loading affects TMJ chondrocyte growth and maturation. We also characterized different cell lineages of condylar cartilage based on the GFP-labeling technique. Our long-term goal is to determine the TMJ cartilage lineage pathways during degeneration and repair. Expertise in the laboratory includes molecular biology, molecular genetics, developmental biology, and bone/cartilage histomorphometry.

Education/Training - Institution/ Location/ Degree: 
D.D.S., Peking Univ, China
Ph.D., Univ. of Conn, Connecticut
Ortho Cert, Univ. of Conn., Connecticut
D.D.S., Columbia University
Selected Peer-reviewed Publications - Three selected citations: 

Chen J, Kalajzic Z, Barasz J, Sobue T, Rowe D, Wadhwa S. Isolation and Characterization of Murine Mandibular Condylar Cartilage Cell Populations. Cells Tissues and Organs. 2012;195(3):232-43. Epub 2011 Jun 1. Chen J, Sobue T, Utreja A, Kalajzic Z, Xu M, Kilts T, Young M, Wadhwa S. Sex Differences in Chondrocyte Maturation in the Mandibular Condyle from a Decreased Occlusal Loading. Calcified Tissue International. 2011 Aug;89(2):123-9. Epub 2011 May 20. Sobue T, Kalajzic Z, Barasz J, Utreja A, Chhibber A, Yeh WC, Chen J, Wadhwa S. Murine Temporomandibular Joint Loading Causes Increased Proliferation and Chondrocyte Maturation. Journal of Dental Research 2011 Apr; 90(4): 512-6. Epub 2011 Jan 19.

Complete list of publications - link to pubmed: 

Chen J, Kalajzic Z, Barasz J, Sobue T, Rowe D, Wadhwa S. Isolation and Characterization of Murine Mandibular Condylar Cartilage Cell Populations. Cells Tissues and Organs. 2012;195(3):232-43. Epub 2011 Jun 1. http://www.ncbi.nlm.nih.gov/pubmed/21646777 Chen J, Sobue T, Utreja A, Kalajzic Z, Xu M, Kilts T, Young M, Wadhwa S. Sex Differences in Chondrocyte Maturation in the Mandibular Condyle from a Decreased Occlusal Loading. Calcified Tissue International. 2011 Aug;89(2):123-9. Epub 2011 May 20. http://www.ncbi.nlm.nih.gov/pubmed/21597908 Sobue T, Kalajzic Z, Barasz J, Utreja A, Chhibber A, Yeh WC, Chen J, Wadhwa S. Murine Temporomandibular Joint Loading Causes Increased Proliferation and Chondrocyte Maturation. Journal of Dental Research 2011 Apr; 90(4): 512-6. Epub 2011 Jan 19.http://www.ncbi.nlm.nih.gov/pubmed/21248355 Chen J, Gupta T, Barasz JA, Kalajzic Z, Yeh WC, Drissi H, Hand AR, Wadhwa S. Analysis of microarchitectural changes in a mouse temporomandibular joint osteoarthritis model. Arch Oral Biol. 2009 Dec;54(12):1091-8.http://www.ncbi.nlm.nih.gov/pubmed/19896116 Chen J, Trettel L, Kalajzic Z, Gupta T, Wadhwa S. Altered temporomandibular joint loading. In: McNamara JA Jr, Kapila SD, eds. Temporomandibular Disorders and Orofacial Pain: Separating Controversy from Consensus. Monograph 46, Craniofacial Growth Series, Department of Orthodontics and Pediatric Dentistry and Center for Human Growth and Development, The University of Michigan, Ann Arbor, 2009;451-464. Chen J, Sorenson KP, Gupta T, Kilts T, Young M, Wadhwa S. Altered Functional Loading Causes Differential Effects in the Subchondral Bone and Condylar Cartilage in the Temporomandibular Joint from Young Mice. Osteoarthritis Cartilage. 2009 Mar; 17(3):354-61. http://www.ncbi.nlm.nih.gov/pubmed/18789726