Wound Healing

Biomaterial parameter variations may result in sustained delivery of appropriate doses of biomolecules, with an improved capacity of wound-healing

Transforming growth factor (TGF) beta-3 induced inhibition of osteogenic differentiation. (A, C, and E) Human mesenchymal stem cells in osteogenic culture and empty PLGA microspheres increased alkaline phosphatase (ALP) staining and mineral deposition. (White arrows, mineral deposition; yellow arrows, alkaline phosphatase). (B, D, and F) Suppression of osteogenesis by released TGF beta-3 from PLGA microspheres (30mg of high-concentration microspheres: 1.35 ng/mL released after 1 week) (ALP stain, red; von Kossa, black). (Source)